Week two in the NFL was host to many good games, but multiple teams were hit by the injury bug.

The San Fransisco 49ers got the brunt of it. The 49ers beat the Jets on Sunday, but the win cost them, four key players. quarterback Jimmy Garoppolo went down with an ankle injury, running back Raheem Mostert left the game in the game with an apparent knee injury. However, the worst injuries happened to their defensive line. Pass-rushers Solomon Thomas and Nick Bosa both went down with apparent ACL tears. Bosas was confirmed Monday.

New York Giants superstar running back Saquon Barkley tore his ACL and will be out for the season. Barkley was not a factor in a week one loss to the Steelers on MNF. The Giants signed free-agent running back Devonta Freeman. Freeman is a former all-pro for the Atlanta Falcons, helping Atlanta reach the Superbowl. Sterling Shepard was also ruled out with a toe injury.

First-round rookie Justin Herbert started the game under center for the Chargers after veteran quarterback Tyrod Taylor sat out due to a chest injury suffered before the game. Taylor is now listed as “week-to-week.” Chargers coach Anthony Lynn said the team will go back to Taylor as a starter as soon as he is healthy enough to do so. Herbert almost collected his first NFL win in the game against the defending champ Kansas City Chiefs. Lynn said that Taylor would start the next game, but it was announced on Wednesday that Herbert would start week three against the Carolina Panthers. Herbert gets the start after the Chargers doctor accidentally punctured Tyrod Taylor’s lung while giving him an injection for pain.

Another major injury on Sunday was Carolina Panthers running back, Christian McCaffrey. McCaffrey went down with an ankle injury and was placed on IR on Wednesday, which means he can come back after three weeks. However, he is actually expected to miss four to six weeks, confirmed as of Wednesday that he suffered a high ankle sprain. Backup running back Mike Davis will assume McCaffrey’s position.

Colts wide receiver Parris Campbell was carted off the field in the first quarter of Indy’s matchup with the Minnesota Vikings. Reports say that Campbell suffered an MCL injury. Colts insider Jim Ayello added there is a “low percent chance” Campbell returns this season. Indy has also lost safety Malik Hooker due to an Achilles injury. He did not return, and it was been reported on Monday he suffered a torn ACL and will miss the 2020 season. These players are two integral parts of the Colts team.

The Denver Broncos were hit hard Sunday, as they lost both wide receiver Courtland Sutton and quarterback Drew Lock. Sutton tore his ACL. Lock injured his throwing shoulder and will be out two to six weeks, although, it has been reported that he could be back a little sooner. Blake Bortles was signed by the Broncos, but Denver also has Jeff Driskel. It is a tossup between the two on who will start in week three.

The Miami Dolphins lost their highest-paid player, CB Byron Jones, to a groin injury Sunday. Not much information about the injury has come out. All we know is that it is a groin injury, and Jones will be out for week three. Jones became a star while with the Dallas Cowboys. Miami signed him to a hefty five-year, $82.5mm deal this past offseason. Rookie first-rounder Noah Igbinoghene will assume the starting role.

Seattle Seahawks linebacker Bruce Irvin suffered an ACL tear and will miss the rest of the season. Irvin is a key cog in the seahawks defense and will be missed. The Seahawks face the Dallas Cowboys on Sunday and will look to attack Dak Prescott and his o-line who have taken some hits themselves.

The Washington Football Team lost G. Brandon Scherff to an MCL sprain and was placed on IR by the team. The loss of Scherff, who is a three times pro-bowler, is a big blow to Washington’s line.